Figure 1 | Genetics in Medicine

Figure 1

From: Excess of runs of homozygosity is associated with severe cognitive impairment in intellectual disability

Figure 1

Single data sets and combined analysis for global homozygosity and mean length of ROH stretches. For each analysis, we reported the number of individuals (n), the estimated changes in odds ratio (OR), and the 95% confidence intervals (95% CIs). On right side, we reported the meta-analysis forest plots. Squares represent the OR for each data set, and their size is proportional to contribution of each data set; horizontal lines are the respective CIs. The diamond represents the summary measurement. In a, the result of global homozygosity analysis is reported, and an increase of 10 Mb in KB was considered. In b, the mean length of ROH is reported, with the increase in KBAVG set to 100 Kb. In both cases, the summary measurements were significantly >1, although it is clear that the signal is stronger in b than in a. KBAVG, the mean length of ROH segments; OR, odds ratio; ROH, run of homozygosity.

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