Figure 1

Bioinformatics filtering and medical review of genes and alterations produced by exome sequencing. Bioinformatics and analysis variant classification schema. ACMG, American College of Medical Genetics and Genomics; AD, autosomal dominant; AR, autosomal recessive; ESP, NHLBI GO Exome Sequencing Project; HGMD, Human Gene Mutation Database; MAF, minor allele frequency; XLD, X-linked dominant; XLR, X-linked recessive; YL, Y-linked; 1000 Genomes, 1000 Genomes Project.