Figure 3

Spectrum and distribution of SDH germ-line mutations reported in more than one SDH -deficient tumor type. (a) Mutations causally related to more than one SDH-deficient tumor type: percentages of mutations observed in the different tumor types (A.1); percentages of mutations in each SDH gene and of the different types of mutations (A.2); and percentages of the different mutation types for each SDH gene (A.3). (b) Mutations harbored by single patients suffering from more than one SDH-deficient tumor type: percentages of mutations in each SDH gene and of the different types of mutations (B.1) and percentages of the different mutation types for each SDH gene (B.2).