Figure 1

Median age of onset of symptoms, diagnosis, and treatment by phenotype. (a) All regions, (b) Asia Pacific, (c) Europe, (d) Latin America, and (e) North America. Median age in years (left axis) calculated on the basis of patients within each phenotype for whom age of symptom onset, diagnosis, or treatment was recorded. The median age in years is noted above each column. The number of patients, n, is noted below each column. In b, the median age of symptom onset is higher than the median age of diagnosis for the five Hurler–Scheie patients, even though all five had an age of symptom onset less than or equal to the age at diagnosis, because data for age of symptom onset were not available for one patient.