Figure 2
From: Ciliopathy variant burden and developmental delay in children with hypoplastic left heart syndrome
Percentile of ciliopathy gene list as compared to random gene lists. To estimate the significance of a C-score difference between our developmentally delayed and nondelayed patient groups, null permutation was performed by randomly selecting a gene list of equal size (N = 14) from the subject’s exome data sets and computing the difference in average C-score 2 million times. The red line indicates that the ciliopathy gene list (with a difference between groups of 2.027) falls at the 99.14 percentile. Nearly one in five random gene lists had no difference in C-score. This symmetrical distribution indicates that the two patient groups have similar levels of variation across the genome.
