Figure 3
From: Prediction of CYP2D6 phenotype from genotype across world populations
CYP2D6 phenotype prediction from genotype data. An activity score (AS) was assigned to each genotype (no, ↓, ↔, and ↑ indicate genotypes with no-, decreased-, normal-, and/or increased-function allele combinations). Panel a shows average frequencies for the different allele combinations and their respective phenotype classifications into poor (gPM), intermediate (gIM), normal-slow (gNM-S), normal-fast (gNM-F), and ultrarapid (gUM) metabolizer groups. The prefix “g” indicates that the phenotype is predicted from genotype. For panel b, genotypes giving rise to AS = 1 or AS = 2 were grouped as indicated. Panel c depicts the translation of genotype or AS into phenotype according to the classification used in CPIC guidelines. Note that genotypes falling into the AS = 1 group are inconsistently classified as gIM or gNM throughout the literature.
