Figure 2

Intratumoral cytogenetic clones algorithm and distribution. (A) Diagram of the intratumoral cytogenetic clones: a discrepancy of more than 30% between each cytogenetic aberration was the cutoff for subclone definition. If the discrepancy of involved cells between each aberration is less than 30 percentage points, then one cytogenetic clone is considered (a, c, and e). If the discrepancy is more than 30 percentage points, then the cytogenetic aberration with the maximal percentage of involved cells is defined as the major clone, whereas that with the least is defined as the minor clone (b, d, and e). The aberrations in the middle are defined as intermediate clones (d). (B) Distribution of intratumoral cytogenetic subclones among the 330 patients.