Figure 2

Structure of 2-[2-nitro-4-trifluoromethylbenzoyl]-1,3-cyclohexanedione (NTBC, nitisinone). mw: molecular weight. IC₅₀: The molar concentration of NTBC that will inhibit 50% of the enzymatic activity of p-OH-phenylpyruvic acid oxidase. T_1/2: The half-life of NTBC concentration in the plasma of healthy young adults.