Figure 3: Molecular modeling of LINGO1 protein. | Genetics in Medicine

Figure 3: Molecular modeling of LINGO1 protein.

From: Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay

Figure 3

(a) A visual inspection of the structure suggests that both variants might interfere with glycosylation process or the recognition of the glycosylation site. Yellow spheres represent p.Arg290 and p.Tyr288, whereas glycan chain is in red and other glycan chains are also shown in sphere representation. (b) Tetrameric structure of lingo-1. Glycan on residue 264 not shown. The protein was visualized with the University of California–San Francisco Chimera software.

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