Table 5 Summary of logistic regression analyses predicting interest in learning each category of secondary findings with low or no medical actionability (versus no interest in learning each category) (N = 152)

From: The who, what, and why of research participants’ intentions to request a broad range of secondary findings in a diagnostic genomic sequencing study

 

Categories

 

A

B

C

D

E

F

Variables

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

Sociodemographics

 Sex (female)

—

—

—

—

—

—

—

—

0.24

0.09, 0.65

—

—

 Age

—

—

—

—

0.98

0.95, 1.00

—

—

—

—

—

—

 Race/ethnicity (non-Hispanic white)

—

—

—

—

—

—

—

—

—

—

—

—

 Education (4-year college degree or greater)

—

—

—

—

—

—

—

—

—

—

—

—

 Income

1.07

0.91, 1.27

1.09

0.92, 1.30

—

—

—

—

—

—

—

—

 Marital status (married)

—

—

—

—

—

—

1.42

0.57, 3.54

—

—

—

—

 Health insurance (have it)

—

—

2.01

0.53, 7.65

—

—

—

—

—

—

—

—

Clinical variables

 Physical functioning

1.17

87, 1.56

1.24

0.93, 1.66

—

—

—

—

—

—

—

—

 Prior genetic testing (yes)

—

—

1.50

0.65, 3.42

—

—

2.24

0.92, 5.46

2.89

1.23, 6.80

—

—

 Positive diagnostic result

1.86

0.82, 4.27

—

—

—

—

0.44

0.12, 1.61

0.48

0.15, 1.60

—

—

 Negative diagnostic result

—

—

—

—

—

—

—

—

—

—

—

—

Uncertain diagnostic result

—

—

—

—

—

—

—

—

—

—

—

—

Literacy

 General health literacy (≥9th-grade reading level)

2.09

0.59, 7.38

1.94

0.57, 6.62

1.63

0.53, 5.04

2.60

0.72, 9.35

—

—

—

—

 Objective numeracy

1.22

0.81, 1.85

1.03

0.68, 1.56

1.53

1.05, 2.23

1.44

0.95, 2.19

 

—

—

—

 Secondary findings knowledge

1.04

0.85, 1.27

0.96

0.77, 1.20

1.01

0.83, 1.23

1.03

0.84, 1.27

—

—

—

—

Anticipated regret

 For not learning findings in category

2.01

1.48, 2.71

2.16

1.59, 2.94

1.61

1.20, 2.16

1.96

1.42, 2.70

1.78

1.32, 2.40

1.72

1.31, 2.26

 For learning findings in category

0.17

0.52, 0.98

0.68

0.49, 0.95

0.70

0.54, 0.92

0.50

0.37, 0.68

0.53

0.39, 0.73

0.54

0.40, 0.71

  1. CI, confidence interval; OR, odds ratio.
  2. Only variables associated with a given outcome at the P < 0.10 level were entered into the logistic regression model for that outcome. Dashes indicate that a variable was not sufficiently correlated with an outcome to be included in its model.
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