Table 2 Hazard ratio (95% confidence interval) of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1
From: Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1
POLE | POLD1 | POLE p.Leu424Val | |
|---|---|---|---|
Overall HR (95%CI) | 12.2 (7.35–20.2) | 87.2 (15.3–495) | 131 (71.3–242) |
Sex | |||
Male | 12.3 (5.35–28.1) | 723 (102–5140) | 75.0 (37.9–149) |
Female | 12.1 (5.64–16.1) | 75.0 (19.2–292) | 269 (111–651) |
P difference | 0.9 | 0.1 | 0.03 |
Age | |||
<50 years | 38.7 (17.5–85.4) | 201 (62.0–651) | 238 (95.6–593) |
≥50 years | 8.21 (4.24–15.9) | 3.34 (0.22–50.1) | 98.0 (44.1–218) |
P difference | 0.003 | 0.007 | 0.2 |
