Figure 2
Dual scatter plots for the differential diagnosis between Krabbe disease and false-positive cases. (a) 6-plex dual scatter plot; (b) 10-plex dual scatter plot. Each plot is divided into four quadrants. Lower right: consistent with Krabbe disease (light blue squares and circles); upper right: indeterminate (both conditions are possible); upper left: consistent with false-positive cases (purple squares and circles); lower left: neither condition. Red diamonds indicate the score of one confirmed Krabbe patient not diagnosed as part of this study. Educational material describing the principle of a min-max score and the creation and use of this tool is available online.40 FP GALC, false-positive result for galactocerebrosidase deficiency.
