Fig. 2
From: Gastric cancer in individuals with Li-Fraumeni syndrome
Pedigree plots of three families (Families 4, 8, and 11) with multiple cases of early-onset gastric cancers and a known TP53 mutation. The circles represent females, whereas the squares represent males. Open symbols indicate no neoplasm and filled symbols represent those with cancer; crossed symbols indicate deceased individuals. Arrows indicate probands, all positive for a TP53 mutation. STO/GEJ, stomach/gastroesophageal junction cancer; BR, breast cancer; SS, soft-tissue sarcomas; OS, osteosarcoma; CNS, central nervous system cancer; CO, colon cancer; PAN, pancreatic cancer; LG, lung cancer; ENDO, endometrial cancer; KID, kidney tumor; PR, prostate cancer; ACC, adrenal cortical cancer; TC, thyroid cancer. Numbers after the symbols for the type of cancer indicate age at death or age at diagnosis. The pedigrees have been deidentified to protect confidentiality. The pedigree of Family 8 has been previously published.35
