Fig. 1

Estimated excess venous thromboembolism (VTE) events attributable to oral contraceptive (OC) use in premenopausal women with and without Factor V Leiden (FVL) and to hormone replacement therapy (HRT) in postmenopausal women with coronary heart disease with and without FVL. Estimates of excess VTE events assume a baseline incidence of 1 VTE/10,000 women/year in premenopausal women and 23 VTE/10,000 women/year in postmenopausal women without either risk factor.75,117,136