Fig. 3

Genomic load differs significantly within and between disease categories. x axis: disease category and y axis: percent deviation from expected genetic load (nonsynonymous variants) for each genome by and by category. Overall, genes in disease categories on average contained 50% fewer variants than expected by chance, thus the y axis is set to cross at 50% to clearly show the differences between categories. Data for individual genomes are plotted according to their listed order in Table 1 and color coded by ethnicity.