Fig. 3 | Genetics in Medicine

Fig. 3

From: Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project

Fig. 3

R4S analyte comparison tool for the amino acid phenylalanine in neonatal dried blood spots. Each box represents the interval between the 10%ile and 90%ile, the upper and lower lines extend to the 99%ile and 1%ile, respectively. The median is shown as a white circle in the body of the box. Color coding: dark green: cumulative percentiles; light green: percentiles of individual participants, sorted in descending order of the 99%ile value; orange: cutoff target range (see text for details); light blue diamonds: actual cutoff values of participants; the marker size is proportional to the number of laboratories using the same value; and bright red bars: disorder ranges (partially hidden by Y-axis reduction to allow the normal percentiles to be visible). For the number of cases included in each disorder range, see Table 2. Abbreviations are listed in the legend of Figure 2.

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