Fig. 2 | Genetics in Medicine

Fig. 2

From: Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

Fig. 2

Phylogenetic conservation of the variant amino acid. A multiple sequence alignment of the region of the XIAP protein containing the variant. The human reference sequence is provided on the first line, with the patient's XIAP sequence listed directly below as “Var XIAP.” This is followed by the XIAP sequence from other species. The cysteine is conserved in all species identified. The C-Y substitution is visible in blue at position 231.

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