Fig. 1 | Genetics in Medicine

Fig. 1

From: Diagnosis and management of familial Mediterranean fever: Integrating medical genetics in a dedicated interdisciplinary clinic

Fig. 1

Hypothesized route of migration of familial Mediterranean fever (FMF) founder mutations. Darkened circle marks the hypothesized origin of the three ancient FMF mutations. Dashed lines represent proposed migration of the founder mutations by land and sea migration. Adapted from Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet 1998;351:659–664 and Ben-Chetrit E, Lerer I, Malamud E, Domingo C, Abeliovich D. The E148Q mutation in the MEFV gene: is it a disease-causing mutation or a sequence variant? Hum Mutat 2000;15:385–386.

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