Fig. 3

Prediction by model. Model predictions relative to therapeutic observed dose are shown for both the clinical-only (•) and genetic + clinical (○) models. Results are scaled, such that perfect prediction of dose results in the value 1. Results for the same subject are connected with a vertical line. Subjects are sorted by model difference, with 61 subjects where the clinical-only model gave the best prediction to the left of the vertical reference line and 115 subjects where the genetic + clinical model gave the best prediction to the right. Prediction errors were significantly smaller on average when the model included genetics (P < 0.0001).