Figure 2 | Gene Therapy

Figure 2

From: A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein

Figure 2

Immunofluorescence with monoclonal antibody decay-accelerating factor (mAbDAF; a, c) and a recombinant minibody version of mAbDAF (b) demonstrating expression of DAF by Chinese hamster ovary (CHO)/DAF (a, b) but not by normal CHO (c) cells. Fluorescence microscopy demonstrating levels of CHO (d–g) or CHO/DAF (h–o) cell infection by HSV1716B (g, k, o) or by Vero cell propagated HSV1716CD20 (d, h), HSV1716CD38 (e, i) or HSV1716DAF (f, j, l–n). CHO/DAF cells were pre-incubated in mAbDAF (m, o), recombinant mAbDAF (n) or mAbCD20 (l).

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