Table 2 Comparisons of average tumour volumes from nude mice with subcutaneous A431 tumours injected intraperitoneally with either HSV1716EGFR or HSV1716

From: A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein

Day

HSV1716EGFR average tumour volume ±s.d.

HSV1716 average tumour volume ±s.d.

P-value

Significant?

8

71.4±35.4

120.1±24.3

0.259

No

10

62.9±22.8

160.0±32.4

0.051

No

13

113.2±18.8

296.9±57.6

0.030

Yes

14

140.6±27.6

363.2±70.1

0.032

Yes

15

203.6±46.8

563.0±117.2

0.038

Yes

17

244.4±60.7

736.8±156.2

0.033

Yes

20

387.7±107.3

843.0±142.1

0.040

Yes

  1. Statistical analysis (ANOVA) was not possible after day 20 as most of the HSV1716-injected mice had died.
Back to article page