Figure 4 | Gene Therapy

Figure 4

From: Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1

Figure 4

Indicated cell lines expressing luciferase were infected with vaccinia (vvDD; MOI 5.0) for the indicated times before supernatant was removed, filter sterilized and added to fresh cells of the same cell line (media from uninfected cells was used as a control). Serial dilutions of paclitaxel were added to these cells and survival measured by bioluminescence imaging (and confirmed by MTS assay, not shown) after 48 h. Samples run in triplicate and graphs shown are representative of two independent experiments; *P<0.05. (a) HCT 116 (b) panel of human and murine tumor cell lines.

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