Table 1 LNA-ONs used in the study

From: Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection

Compounds

Sequences

Targets

EZN-3920

5′-TAGcctgtcacttCTC-3′

HER3

EZN-4454 (control for EZN-3920)

5′-TAGcctttgacctCTC-3′

None

EZN-4455 (control for EZN-3920)

5′-TAGcttgtcccatCTC-3′

None

EZN-3046 scrambled control

5′-CGCAgattagaaACCt-3′

None

EZN-3889

5′-CCAtcttgtgatcCAT-3′

β-catenin

EZN-4516

5′-GGCacagccagtgGCG-3′

HSP27

EZN-4150

5′-AGCcattcattccACC-3′

PIK3CA

  1. Abbreviations: LNA, locked nucleic acid; ON, oligonucleotide. All ONs except EZN-3889 correspond to complementary coding region of their respective mRNA sequence. All ONs are 100% match to their mouse mRNA. The ONs have fully thiolated backbone.
  2. The small caps in the sequences indicate DNA while caps indicate LNA. The quantification of the ONs was performed by measuring OD260 nm value on an UV NanoDrop spectrometry ND-1000 (NanoDrop Technologies, Inc., Wilmington, DE, USA).
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