Table 3 Histological analysis of remote LV myocardium in non-infarcted control C57BL/6 LDLr−/− mice and in control and AdLDLr-treated female C57BL/6 LDLr−/− mice 7 days and 28 days after MI
Non-infarcted | 7 Days after MI | 28 Days after MI | |||
---|---|---|---|---|---|
Control (n=11) | Control (n=9) | AdLDLr (n=9) | Control (n=21) | AdLDLr (n=22) | |
Cardiomyocyte cross-sectional area (μm2) | 220±21 | 200±6.4 | 170±9.0* | 250±9.4### | 210±6.8**## |
Cardiomyocyte density (number mm−2) | 4600±340 | 3900±120 | 4600±210** | 3500±110§ | 3900±92*## |
Capillary density (number mm−2) | 6000±400 | 4400±220§§ | 5600±320* | 5000±220§ | 5700±170* |
Relative vascularity (μm−2) | 0.0064±0.00053 | 0.0058±0.00030 | 0.0071±0.00042* | 0.0059±0.00027 | 0.0071±0.00026** |
Collagen deposition (% of total LV remote area) | 1.9±0.084 | 4.0±0.17§§§§ | 3.1±0.14**§§§§ | 4.1±0.22§§§§ | 3.3±0.20*§§§ |
Leukocyte infiltration (number mm−2) | 340±25 | 700±63§§§ | 520±46*§ | 410±23## | 420±51 |