Table 3 Histological analysis of remote LV myocardium in non-infarcted control C57BL/6 LDLr−/− mice and in control and AdLDLr-treated female C57BL/6 LDLr−/− mice 7 days and 28 days after MI

From: Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

 

Non-infarcted

7 Days after MI

28 Days after MI

 

Control (n=11)

Control (n=9)

AdLDLr (n=9)

Control (n=21)

AdLDLr (n=22)

Cardiomyocyte cross-sectional area (μm2)

220±21

200±6.4

170±9.0*

250±9.4###

210±6.8**##

Cardiomyocyte density (number mm−2)

4600±340

3900±120

4600±210**

3500±110§

3900±92*##

Capillary density (number mm−2)

6000±400

4400±220§§

5600±320*

5000±220§

5700±170*

Relative vascularity (μm−2)

0.0064±0.00053

0.0058±0.00030

0.0071±0.00042*

0.0059±0.00027

0.0071±0.00026**

Collagen deposition (% of total LV remote area)

1.9±0.084

4.0±0.17§§§§

3.1±0.14**§§§§

4.1±0.22§§§§

3.3±0.20*§§§

Leukocyte infiltration (number mm−2)

340±25

700±63§§§

520±46

410±23##

420±51

  1. Abbreviations: AdLDLr, adenoviral LDLr; MI, myocardial infarction; LDLr, LDL receptor; LV, left ventricular.
  2. *P<0.05,**P<0.01 for comparison of control versus AdLDLr-treated mice.
  3. §P<0.05, §§P<0.01, §§§P<0.001, §§§§P<0.0001 for comparison versus non-infarcted mice.
  4. ##P<0.01, ###P<0.001 for comparison of day 7 versus day 28 after MI.
  5. Data are expressed as means±s.e.m.