Table 4 Histological analysis of infarct area in control and AdLDLr-treated female C57BL/6 LDLr−/− mice 7 days and 28 days after MI

From: Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

 

7 Days after MI

28 Days after MI

 

Control (n=15)

AdLDLr (n=15)

Control (n=21)

AdLDLr (n=22)

Capillary density (number mm−2)

490±26

520±28

290±17####

370±22**####

Collagen deposition (% of infarct area)

29±1.4

28±1.9

50±1.9####

49±1.7####

Leukocyte infiltration (number mm−2)

4400±260

3800±230

1200±110####

1100 ± 92####

Myofibroblast infiltration (% of infarct area)

4.4±0.51

4.3±0.37

1.2±0.17####

0.80±0.094####

  1. Abbreviations: AdLDLr, adenoviral LDLr; MI, myocardial infarction; LDLr, LDL receptor.
  2. **P<0.01 for comparison of control versus AdLDLr-treated mice.
  3. ####P<0.0001 for comparison of day 7 versus day 28 after MI.
  4. Data are expressed as means±s.e.m.