Table 5 Hemodynamic parameters in control and AdLDLr-treated female C57BL/6 LDLr−/− mice 28 days after sham operation or MI

From: Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

 

Non-infarcted

28 Days after MI

 

Control

Control

AdLDLr

Left ventricle

 Number of mice

6

16

18

 Mean pressure (mm Hg)

49±1.1

44±2.5

49±2.7

 Peak systolic pressure (mm Hg)

120±2.8

98±3.5§§

110±2.9**

 End-diastolic pressure (mm Hg)

1.1±0.94

6.3±2.0§

5.6±1.7§

 Peak dP/dtmax (mm Hg ms–1)

15±0.76

11±0.59§§

12±0.44*§§

 Peak dP/dtmin (mm Hg ms–1)

−12±1.0

−7.4±0.48§§§§

−8.7±0.32*§§

 Tau (ms)

4.0±0.22

7.0±0.74§§§

6.3±0.46§§§

 Heart rate (b.p.m.)

640±21

600±19

600±12

Aorta

 Number of mice

7

22

22

 Mean pressure (mm Hg)

94±3.0

79±2.6§§

90±2.1**

 Peak systolic pressure (mm Hg)

110±3.4

96±2.6§§

110±2.5*

 Peak diastolic pressure (mm Hg)

79±3.0

64±2.8§§

77±1.9***

  1. Abbreviations: AdLDLr, adenoviral LDLr; MI, myocardial infarction; LDLr, LDL receptor.
  2. *P<0.05,**P<0.01,***P<0.001 for comparison of control versus AdLDLr-treated mice.
  3. §P<0.05, §§P<0.01, §§§P<0.001, §§§§P<0.0001 for comparison versus non-infarcted mice.
  4. Data are expressed as means±s.e.m.