Table 6 Analysis of mRNA expression levels and of lipid peroxidation in the remote LV myocardium in non-infarcted control C57BL/6 LDLr−/− mice and in control and AdLDLr-treated C57BL/6 LDLr−/− mice 28 days after MI
Non-infarcted | 28 Days after MI | ||
---|---|---|---|
Control | Control | AdLDLr | |
Gene expression (mRNA expression normalized to Gapdh) | |||
Agtr1a | 1.0±0.098 | 0.43±0.018§§§ | 0.58±0.033***§§ |
Ctgf | 1.0±0.15 | 9.3±1.1§§§§ | 5.2±0.96*§§§ |
Nox2 | 1.0±0.12 | 2.0±0.21§§ | 1.5±0.22 |
Nox4 | 1.0±0.19 | 9.0±1.2§§§§ | 4.8±0.95*§§§ |
Nppa | 1.0±0.29 | 10±1.3§§§§ | 11±3.1§§§ |
Nppb | 1.0±0.22 | 4.8±0.31§§§§ | 2.6±0.42***§§ |
Sod1 | 1.0±0.10 | 1.2±0.070 | 1.0±0.12 |
Sod2 | 1.0±0.10 | 0.96±0.078 | 1.0±0.079 |
Sod3 | 1.0±0.31 | 1.7±0.20 | 1.6±0.31 |
Lipid peroxidation | |||
MDA (nmol mg protein–1) | 2.5±0.19 | 2.2±0.17 | 2.7±0.17 |