Table 1 Biodistribution following subretinal delivery in pigs (GC mdg−1)
From: AAV-mediated photoreceptor transduction of the pig cone-enriched retina
Treatment | Retina | Optic nerve | Chiasm | Thalamus | Visual cortex | ||
|---|---|---|---|---|---|---|---|
R1 | Left | AAV2/8 | 6.771±0.205 | ND | ND | ND | ND |
R2 | Left | AAV2/8 | Not measured | ND | ND | ND | ND |
R3 | Left | AAV2/8 | 2.340±0.043 | ND | ND | ND | ND |
R4 | Left | AAV2/8 | 2.552±0.126 | ND | ND | ND | ND |
R5 | Left | AAV2/5 | 4.952±0.379 | ND | ND | ND | ND |
Right | AAV2/5 | 34.344±0.094 | 0.491±0.005 | ND | ND | ND | |
R6 | Left | AAV2/5 | 58.104±1.480 | 0.444±0.002 | ND | ND | ND |
Right | AAV2/5 | Not measured | ND | ND | ND | ND | |
P3 | Left | AAV2/5-RHO | Not measured | ND | ND | ND | ND |
Right* | AAV2/5-CMV | Not measured | ND | ND | ND | ND | |
Right | Not Injected | ND | ND | ND | ND | ND |
