Table 1 Summary of morphometric analysis on 28-day vein graft

From: Inhibition of neointimal hyperplasia in a rabbit vein graft model following non-viral transfection with human iNOS cDNA

Group

Surgery

pCI

iNOS

n

7

8

7

Mean I/M (±s.d.)

0.43±0.12

0.53±0.19

0.22±0.08

Change in I/M (iNOS vs controls)

−49% (P<0.05)

−58% (P<0.001)

—

Change in I/M (pCI vs surgery)

+23% (NS)

  

Mean area I (mm2; ±s.d.)

0.56±0.24

0.78±0.25

0.20±0.06

Change in area I (iNOS vs controls)

−64% (P<0.05)

−74% (P<0.001)

 

Change in area I (pCI vs surgery)

+39% (NS)

  
  1. Abbreviations: I/M, intima-to-media ratio; gene for iNOS, inducible nitric oxide synthase; NS, not significant; pCI, control plasmid, pCI.
  2. The means (±s.d.) of the ratio of I/M and the area of neointima (I mm2) from all the three groups were determined and compared with the surgery control group and the pCI plasmid control group. The percentage of changes in each value are shown for iNOS treatment compared with each control. Statistical analysis was performed by one-way analysis of variance with Bonferroni’s post-test analysis. One value for I mm2 was removed from the iNOS group as its value was >2 s.d. values beyond the mean.
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