Figure 3 | Gene Therapy

Figure 3

From: Effect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy

Figure 3

Toluidine blue-stained semithin sections observed in light microscopy (a–d) and electron microscopy (e–h) images of MIV-LacZ (c, d, g, h) and MIV-VEGF (a, b, e, f) conduits 3 months after surgery. In MIV-VEGF there are a lot of muscle fibers still in the conduit that have well-organized sarcomeres and intact mitochondria. Some myotube with central nucleus are also detectable inside the MIV-VEGF conduit (arrow). In MIV-LacZ conduit the very few muscle fibers that can be observed have different sign of atrophy, such as sarcomeric disorganization, vacuolization and mitochondria destruction. Scale bars: (a and c): 50 μm; (b and d): 20 μm; (e and g):5 μm; (f and h):1 μm.

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