Table 4 Hemodynamic parameters in the left ventricle and in the aorta on day 28 after myocardial infarction in comparison with reference values in sham C57BL/6 LDLr−/− mice

From: Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice

 

Sham (n=19)

Control MI (n=11)

AdA-I MI (n=11)

Left ventricle

 Peak systolic pressure (mm Hg)

103±2

84.9±2.6§§§

95.9±3.8*

 End-diastolic pressure (mm Hg)

2.19±0.68

4.81±1.75

1.92±0.92

 Peak dP/dt max (mm Hg ms−1)

12.1±0.6

6.60±0.27§§§

9.01±0.54§§**

 Peak dP/dt min (mm Hg ms−1)

−8.7±0.38

−5.57±0.23§§§

−7.32±0.48§**

 Tau (ms)

5.19±0.29

6.90±0.35§§

5.75±0.31*

 Heart rate (bpm)

601±15

554±23

573±26

Aorta

 Mean pressure (mm Hg)

78.8±2.1

64.3±2.6§§

78.4±4.2**

 Peak systolic pressure (mm Hg)

99.5±2.0

81.0±2.3§§§

96.1±4.4**

 Peak diastolic pressure (mm Hg)

60.2±2.7

50.6±3.3

63.2±3.5*

  1. Abbreviations: LDLr, low-density lipoprotein receptor; MI, myocardial infarction.
  2. Data are expressed as means±s.e.m. *P<0.05; **P<0.01 for comparison versus control MI. §P<0.05; §§P<0.01; §§§P<0.001 versus Sham.
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