Table 5 Comparison of infarct parameters and of left ventricular remodelling at day 28 after myocardial infarction in mice without and with prior irradiation and bone marrow transplantation

From: Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice

 

No prior bone marrow transplantation

Prior bone marrow transplantation

 

Control MI (n=16)

AdA-I MI (n=16)

Control MI (n=16)

AdA-I MI (n=14)

Infarct area (mm2)

3.06±0.16

2.84±0.26

2.44±0.17§

2.05±0.17§

Infarct length (μm)

9750±580

7430±800*

5000±280§§§§

4220±250§§*

Infarct thickness (μm)

270±12

379±25***

590±24§§§§

613±17§§§§

Whole left ventricular area (mm2)

26.3±1.5

23.0±0.9

19.2±0.5§§§

17.5±0.5§§§§*

Left ventricular cavity area (mm2)

16.2±1.5

11.7±1.3*

7.30±0.58§§§§

5.98±0.40§§§

Left ventricular muscle area (mm2)

7.08±0.60

8.49±0.65

9.44±0.36§§

9.46±0.32

Septal wall thickness (μm)

1060±30

1240±60

1100±30

1150±40

Cardiomyocyte cross-sectional area (μm2)

405±16

399±17

293±12§§§§

282±12§§§§

Capillary density (number mm−2)

4140±270

4620±290

3380±180§

3550±170§§

  1. Abbreviation: MI, myocardial infarction.
  2. Data are expressed as means±s.e.m. *P<0.05; ***P<0.001 for control MI versus AdA-I MI. §P<0.05; §§P<0.01; §§§P<0.001; §§§§P<0.0001 for prior bone marrow transplantation groups versus respective no prior bone marrow transplantation groups.
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