Table 1 Intratumoral gene therapy vectors and cancer types

From: Intratumoral gene therapy versus intravenous gene therapy for distant metastasis control with 2-Diethylaminoethyl-Dextran Methyl Methacrylate Copolymer Non-Viral Vector–p53

Author

Vector

Cancer type

Ref.

Hecht et al.

TNFerade (AdGVEGR, TNF.11D)

Pancreas

40

Hanna et al.

BC-819

Pancreas

41

Li et al.

oHSV-1-NIS

Prostate

45

Leifler et al.

Adenovirus carrying TIMP-1 or MMP-9

Breast

42

Peng et al.

miRNA or shRNA-against target gene (Beclin 1)

Hepatocellular

43

Weibel et al.

GLV-1h68

Different tumor models

39

Puntel et al.

HC-Ad-TK/TetOn-Flt3L

Glioblastoma

47

Hallet et al.

Anti-MMP-9 DNAzyme

Breast

46

Chen et al.

PDMSCs-PEDF

Melanoma

44

Xie et al.

Ad-IFN-γ

Pancreas

11

Yang et al.

Hu 14.18-IL-2

NXS2 neuroblastoma cell line

31

Kasai et al.

MGH2.1-CPA-CYP2B1 and CPT11-shiCE

Glioma cells

50

Ramachandran et al.

HP-NAP, Ad5PTDf35-[Δ24-sNAP]

Neuroendocrine

49

Huang et al.

shVEGF-DOX-dtACPP

Glioma

48

  1. Abbreviations: Ad-IFN-γ, adenovirus-interferon-γ; BC-819, a plasmid comprised of the H19 gene regulatory sequences; DOX, doxorubicin; dtACPP, nanoparticle; GLV-1h68, Vaccinia virus strain; HC-Ad-TK/TetOn-Flt3L, adenoviral vectors encoding cytotoxic herpes simplex type 1 thymidine kinase and the immunostimulatory cytokine fms-like tyrosine kinase ligand 3; HP-NAP-Ad5PTDf35-[Δ24-sNAP], Helicobacter pylori neutrophil-activating protein, which mediate antitumor effects by recruiting neutrophils and inducing Th1-type differentiation in the tumor microenvironment; Hu 14.18-IL-2, an immunocytokine consisting of human interleukin-2 linked to hu14.18 mAb, which recognizes the disialoganglioside; MGH2.1, a herpes simplex oncolytic virus type 1 expressing two prodrug-activating transgenes: (a) cyclophosphamide activating P4502B1 and (b) CPT11-activating secreted human intestinal carboxylesterase; MM9, matrix metalloproteinase-9; oHSV-1-NIS, oncolytic herpes simplex virus type 1 with gene coding for human sodium iodide symporter (NIS); PDMSCs-PEDF, placenta-derived mesenchymal stem cells loaded with ecombinant adenoviruses expressing pigment epithelium-derived factor; shVEGF, interfering RNA targeting vascular endothelial growth factor; TIMP-1, tissue inhibitor of metalloproteinase-9; TNFerade (AdGVEGR, TNF.11D), a replication-deficient adenoviral vector that expresses tumor necrosis factor-α.
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