Table 5 Tumor measurement from experiment initiation and every 7 days

From: Intratumoral gene therapy versus intravenous gene therapy for distant metastasis control with 2-Diethylaminoethyl-Dextran Methyl Methacrylate Copolymer Non-Viral Vector–p53

 

First measurement

Second measurement

Third measurement

C1

7.5 × 5.8 (126.15)

25.6 × 12.1 (1874.05)

42.4 × 23.5 (11 707.7)

C2

10 × 9.3 (432.45)

23.2 × 15.3 (2715.44)

 

C3

9.2 × 4.7 (101.61)

24.1 × 19.3 (4488.5)

34.3 × 26.5 (12 043.59)

C4

6.3 × 3.2 (32.26)

21 × 17.5 (3215.63)

 

C5

10.3 × 7.4 (282)

29.4 × 22.3 (7310.16)

43.2 × 32.7 (23 096.66)

C6

6.5 × 3.4 (37.57)

21.7 × 18.1 (3554.57)

38.1 × 27.1 (13 990.51)

C7

6.4 × 3.8 (46.2)

21.9 × 17.6 (3391.87)

37.7 × 26.2 (12 939.39)

C8

9 × 4.2 (79.38)

23.8 × 18.9 (4250.8)

33.9 × 25.7 (11 195.3)

C9

6.1 × 3 (27.45)

20.1 × 17.2 (2973.19)

 

C10

9.7 × 4.4 (93.9)

24.4 × 19 (4404.2)

41.7 × 23.6 (11 612.62)

1.1

6.2 × 3.7 (42.44)

19.1 × 18.5 (3268.49)

27.2 × 25.8 (9052.7)

1.2

11.3 × 5.4 (164.75)

  

1.3

12.3 × 7.2 (318.82)

12.8 × 12.2 (952.58)

 

1.4

9.1 × 6.3 (180.59)

13.8 × 13 (1166.1)

26.6 × 22 (6437.2)

1.5

5.7 × 4.8 (65.66)

13 × 7.5 (365.63)

25.8 × 17.5 (3950.63)

1.6

11.2 × 6.4 (229.38)

11.5 × 10.8 (670.68)

 

1.7

5.5 × 4.4 (53.24)

12.2 × 8.1 (400.22)

24.9 × 18.2 (4123.94)

1.8

10.5 × 5.2 (141.96)

13.8 × 8.2 (463.96)

25.9 × 17.8 (4103.08)

1.9

6.2 × 5.1 (80.63)

13.1 × 7.9 (408.79)

25.6 × 17.3 (3830.91)

1.10

9.2 × 6.1 (171.17)

14 × 13.2 (1219.68)

27 × 21.7 (6357.02)

2.1

6.8 × 3.5 (41.65)

20.6 × 15.8 (2571.29)

 

2.2

10 × 6.7 (224.45)

19.3 × 15.6 (2348.42)

27.5 × 21.8 (6534.55)

2.3

9.4 × 4.8 (108.29)

16 × 14 (1568)

26.6 × 23.7 (7470.48)

2.4

8.9 × 5.1 (115.74)

16.7 × 15.7 (2058.19)

26.7 × 19.6 (5128.54)

2.5

7.1 × 4.9 (85.24)

20.5 × 14.7 (2214.92)

27.5 × 24.6 (8320.95)

2.6

8.7 × 4.7 (96.09)

16.5 × 15.1 (1881.08)

26.4 × 19.1 (4815.49)

2.7

6.5 × 3.6 (42.12)

20.1 × 15.9 (2540.74)

 

2.8

9.8 × 6.3 (194.48)

19.1 × 15.2 (2206.43)

27.3 × 21.5 (6309.71)

2.9

9.1 × 4.9 (109.25)

16.1 × 14.3 (1646.14)

26.8 × 23.9 (7654.21)

2.10

7.3 × 5.2 (98.7)

20.7 × 14.9 (2297.8)

27.8 × 24.8 (8549.06)

  1. Tumor volume measurements in mm3.
  2. Number in parenthesis represents volume measurement after the additional equation ½(length × width2) σɛ mm3.
  3. In groups 1 and 2, tumor growth rate is reduced in comparison to the control.
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