Figure 1 | Gene Therapy

Figure 1

From: CD40 ligand and tdTomato-armed vaccinia virus for induction of antitumor immune response and tumor imaging

Figure 1

Virus construct. (a) Schematic drawing of virus construct vvdd-tdtomato and vvdd-CD40L-tdtomato. Unlike in previous designs (where a mere insertion was employed), a deletion was engineered into the TK open reading (star). (b) In vitro expression of tdTomato 48 h after infection. (c) In vivo expression of tdTomato 48 h. Virus was intratumorally injected in nude mice bearing M4A4-LM3 breast tumors and imaged with a specially constructed in vivo fluorescent imaging device.

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