Figure 5 | Gene Therapy

Figure 5

From: CD40 ligand and tdTomato-armed vaccinia virus for induction of antitumor immune response and tumor imaging

Figure 5

vvdd-hCD40L-tdtomato showed increased antitumor efficacy in CD40-positive tumors following intratumoral administration. Nude mice bearing human tumors were treated with PBS, vvdd-tdTomato and vvdd-hCD40L-tdtomato, and tumor growth was measured over time. Administration of the virus was performed intratumorally. (a) hCD40L-sensitive breast tumors (EJ cell line). (b) hCD40 negative tumors (A549 cell line).

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