Figure 4 | Gene Therapy

Figure 4

From: Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10

Figure 4

All AAV serotypes transduce neurons and astrocytes but not microglia and oligodendrocytes in the cortex. Representative cortical images of AAV5, -8, -9 and -rh10 transduced MPS IIIB animals stained for neurons (NeuN), astrocytes (GFAP), microglia (Iba1) and oligodendrocytes (OSP). Arrows indicate areas of co-localization of each cell type and rAAV-GFP in the cortex of MPS IIIB animals. Images taken with × 40 objective lens, scale bar=60 μm.

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