Figure 4 | Gene Therapy

Figure 4

From: Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge

Figure 4

NP-specific Ad-amiRNAs downregulated CD8+ T-cell response via NP degradation. C57Bl/6 mice (n=5) were immunized with 1 × 1011 vp of Ads-amiRNAs and challenged with 1LD50 of A/PR8 24 h later. Frequency of NP-specific CD8+ T cells (a) or IFN-γ+CD8+ T cells (b) in peripheral blood of C57Bl/6 mice collected 2 or 4 weeks after infection were determined by tetramer staining or intercellular cytokine staining, respectively (one-way ANOVA).

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