Table 2 Biochemical serum parameters of L. donovani-infected and PBS- or LEISHDNAVAX (DNA)-treated mice
From: Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine
Experiment/mouse strain | Treatment (3 doses) | Sampling (days post Infection) | Mice n | Urea mean±s.e.m. (mmol l−1) | Creatinine mean±s.e.m. (μm ol l−1) | ALT mean±s.e.m. (U l−1) | AST mean±s.e.m. (U l−1) |
|---|---|---|---|---|---|---|---|
1/BALB/c | PBS | 28 | 8 | 5.5±0.3 | 9.6±0.8 | 60.0±8.1 | 90.0±35.7 |
|  | DNA | 28 | 7 | 5.4±0.2 | 11.7±1.9 | 74.5±17.2 | 194.6±103 |
2/C57BL/6 | PBS | 28 | 5 | 7.3±0.5 | 18.0±0.9a | 144.6±25 | 176.1±35.5 |
|  | DNA | 28 | 5 | 6.8±0.4 | 13.4±1.2a | 122.0±16.2 | 134.1±15.1 |
3/C57BL/6 | PBS | 28 | 8 | 6.2±0.2 | 10.7±0.6 | 142.8±13.7 | 162.5±12.1 |
|  | DNA | 28 | 7 | 5.6±0.3 | 13.9±1.4 | 156.6±20.1 | 188.9±35.2 |
|  | PBS | 50 | 7 | 7.0±0.4 | 10.0±1.3a | 67.6±8.1 | 90.4±10.9 |
|  | DNA | 50 | 5 | 6.9±0.5 | 14.3±1.2a | 57.6±6.2 | 89.7±8.2 |
