Figure 1 | Gene Therapy

Figure 1

From: Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model

Figure 1

Schematic representation of GT vectors used in this study. The upper part corresponds to the four different OAVs and the lower part corresponds to the HDAd. ΔE1A, deletion of the CR2 domain of the E1A gene; ΔE3, partial deletion of the E3 region; GAL4-E1Bp, inducible promoter comprising four Gal4-binding sites and a TATA box derived from the adenoviral E1B gene; GPI, GPI anchor signal; HPRT and C346, fragments from the human hypoxanthine-guanine phosphoribosyltransferase and C346 cosmid used as DNA stuffer, respectively; IRES, internal ribosomal entry site; ITR, inverted terminal repeat; ψ, packaging signal; p40 and p35, heavy and light chains of IL-12, respectively; miR, target sequence for the miR-122; pA, polyadenylation signal; TM, transmembrane domain from human CD4; TTRp, transthyretin promoter; GLP65, transactivator composed of a Gal4 DNA-binding domain, a human progesterone receptor ligand binding domain and a human p65 activator domain. Not drawn to scale.

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