Figure 5 | Gene Therapy

Figure 5

From: Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model

Figure 5

Incorporation of the target sequence for miR-122 in the 3′ UTR of scIL-12 reduces expression of the cytokine in the liver. Syrian hamsters bearing intrahepatic HaP-T1 tumors were injected intravenously (a) or intratumorally (b) with 109 i.u. of OAV-scIL-12 or OAV-scIL-12-miR. Twenty-four hours later, the animals were killed for collection of liver, tumor and blood. scIL-12 concentration was quantified by ELISA in serum (expressed as ng ml–1, left vertical axis) and in tissue extracts from normal liver or tumors (expressed as ng g–1 tissue, right vertical axis). *P<0.05, **P<0.01.

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