Figure 5
From: Development of novel AAV serotype 6 based vectors with selective tropism for human cancer cells
Analysis of intracellular trafficking of AAV vectors to the nucleus. Ratio of total viral genomes in cytoplasm 2 h post infection: (a) capsid-optimized AAV6 & AAV6-WT vectors for three human cancer cell lines; (b) capsid-optimized AAV6 and WT-AAV6 vectors viral genome distribution at 48 h post infection in three different human cancer cell lines. 3M is Y705-731F+T492V. Cytoplasm – purple, nucleus – yellow. **P<0.001 between nucleus & cytoplasm, #P<0.005 between WT and capsid-optimized AAV, considered significant.
