Figure 6
From: Development of novel AAV serotype 6 based vectors with selective tropism for human cancer cells
In vivo imaging of luciferase after tail vein injection of capsid-optimized AAV6 vectors distribution between human cancer cell and mice hepatocytes. Huh7 cell were xenograft into NSG mice and animals were injected with 5 × 10e10 vg per animal of several most efficient mutants ssAAV6 vectors from Table 1, carrying firefly luciferase gene. Live images were taken to analyze difference in luciferase activity. The visual output represents the number of photons emitted per second per cm2 as a false color image where the maximum is red and the minimum is blue (a) and relative signal intensity (b). *P<0.005 was considered as significant.
