Figure 13 | Gene Therapy

Figure 13

From: A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

Figure 13

Skeletal defects in the PMIS-miR-17-18-19-92 embryos. E18.5 embryos were harvested and bodies were stained with Alcian blue and Alizarin red to detect cartilage and bone, respectively. (a) PMIS-miR-17-18-19-92 embryos show delayed overall ossification, lack of thyroid structures (black arrow) and a loss of the processus angularis (circle) and microcephaly. (b) The PMIS-miR-17-18 mice have normal thyroid development and structures, but the first cervical (C1) vertebra is malformed. The PMIS-miR-19-92 mice have lost the thyroid structures (black arrow), and have a malformed C1 vertebra. The PMIS-miR-17-18-19-92 mice are defective for multiple cartilages and thyroid structures.

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