Figure 14 | Gene Therapy

Figure 14

From: A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

Figure 14

Working model for inhibitor complex. The mature miR is processed and associated with proteins that facilitate its interaction into an RNA-induced silencing complex with the mRNA or the PMIS. The PMIS transiently binds these factors in association with the mature miR. Dicer is associated with AGO2 and TRBP to facilitate transfer of the miR to the PMIS. However, Dicer is released as it cannot cleave the PMIS double-stranded stem. Yellow ellipsoid is AGO protein, green ellipsoid is Dicer protein, and purple ellipsoid is other proteins such as TRBP and PACT. Black line is mature miR, blue line is PMIS-miR inhibitor.

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