Figure 9 | Gene Therapy

Figure 9

From: A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

Figure 9

Schematic of the miR-17-92, miR-106a-363 and miR-106b-25 clusters. (a) The location and organization of the miR clusters are shown in the top panel. (b) The middle panel shows the sequence similarities and differences between the miRs. PMIS-miR-17 and PMIS-miR-18 were derived from miR-17-5p and miR-18a-5p, respectively. PMIS-miR-19 and PMIS-miR-92 were derived from miR-19a-3p and miR-92a-1-3p, respectively. (c) The structure of the construct used for pronuclear injection is shown at the bottom of figure.

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