Figure 1 | Gene Therapy

Figure 1

From: Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice

Figure 1

Histological discrimination of human FIX expression from mouse FIX and liver histology of wild-type and mutant control mice. (a) Untreated wild-type mouse left liver lobe stained with hFIX antibody, × 40. (b) Untreated FIX mutant mouse left liver lobe stained with hFIX antibody, × 40. (c) Human FIX UTMD-treated mutant mouse left liver lobe stained with hFIX antibody at 1 day after treatment, × 40. (d, e) Immunofluorescence and H&E-stained left liver lobes from untreated mice demonstrate the absence of hFIX expression and antibody crossreactivity to murine FIX (mFIX). (f) hFIX negative control histology. H&E stain of a mutant mouse liver 1 day after treatment with pZY53-luc and microbubbles (without hFIX) followed by UTMD.

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