Figure 7
From: Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice
APTT values for UTMD hFIX-treated mutant mice. Average clotting times for three time points tested for each group of mutant mice treated with pZY53-hFIX or pmGENIE3-hFIX by UTMD (n=3–4 mice per group, as indicated). Dashed lines indicate baseline average clotting times for untreated wild-type and mutant mice. One mutant control mouse (indicated by open square) was treated with pZY53-luc plasmid only by UTMD and APTT test was performed on plasma 1 day after UTMD as a negative control for hFIX. P=0.001 and P=0.02 for pZY53-hFIX, P=0.012 and P=0.001 for pmGENIE3-hFIX days 4–5 and 12 after UTMD, respectively.
