Figure 9
From: Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice
Long-term APTT evaluation in mutant mice treated with pmGENIE3-hFIX. Open circles indicate average clotting times in mice 1, 4 or 5, 12 and 160 days after treatment with pmGENIE3-hFIX (n=3–4 mice per group, as indicated). Dashed lines indicate baseline average clotting times for untreated wild-type (n=22, black triangle) and mutant (n=6, black square) mice. P=0.012, P=0.001 and P=0.044, days 4 or 5, 12 and 160 after UTMD, respectively, when compared with untreated mutant controls.
