Table 1 APTT mean values for untreated WT and MUT plasma and treated plasma collected days 1, 4 or 5 and 12 for pZY53-hFIX (n=10 total) and pmGENIE3-hFIX (n=12 total) treatments

From: Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice

Controls

Mean APTT

s.d. (s)

(a) Untreated WT and MUT plasma

 Wild-type untreated (n=22)

48.1 s

3.4 s

 Mutant untreated (n=6)

136.1 s

12.1 s

Treatment

D1

s.d.

D4/5

s.d.

D12

s.d.

(b) Treated plasma

 pZY53-hFIX

126.5 s (n=4)

22.7 s

97.0 s (n=3)

3.1 s

108.0 s (n=3)

17.1 s

 pmGENIE3-hFIX

139.4 s (n=4)

10.9 s

111.1 s (n=4)

11.6 s

104.6 s (n=4)

5.6 s

  1. Abbreviations: APTT, activated partial thromboplastin time; D, day; MUT, mutant; WT, wild type.
  2. P<0.001 for untreated WT compared with MUT controls, P=0.483, P=0.001 and P=0.020 for pZY53-hFIX and P=0.660, P=0.0012 and P=0.001 for pmGENIE3-hFIX compared with untreated mutant mice for days 1, 4 or 5 and 12 after ultrasound-targeted microbubble destruction (UTMD), respectively.
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